Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation

Diagnostic utility of LEF1 and β-catenin in WNT pathway tumors with CTNNB1 mutation

Abstract Objective This study aimed to compare the expression of lymphoid enhancer factor 1 (LEF1) and β-catenin in basal cell adenoma (BA), desmoid-type fibromatosis (DF), and pancreatic solid pseudopapillary neoplasm (SPN) to evaluate their diagnostic utility in tumors associated with the WNT/β-ca...

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Bibliographic Details
Main Authors: Can Li, Lingdan Dong, Li Zhu, Wenbin Guan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:World Journal of Surgical Oncology
Subjects:
LEF1
Β-catenin
WNT signaling pathway tumors
CTNNB1 gene mutation
Immunohistochemical marker
Online Access:https://doi.org/10.1186/s12957-025-03675-8
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https://doi.org/10.1186/s12957-025-03675-8

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