Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks

Abstract Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enhancers adopt a primed chromatin state prior to their activation. How this primed enhancer st...

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Main Authors: Christopher D. Todd, Jannat Ijaz, Fereshteh Torabi, Oleksandr Dovgusha, Stephen Bevan, Olivia Cracknell, Tim Lohoff, Stephen Clark, Ricard Argelaguet, Juliette Pierce, Ioannis Kafetzopoulos, Alice Santambrogio, Jennifer Nichols, Ferdinand von Meyenn, Ufuk Günesdogan, Stefan Schoenfelder, Wolf Reik
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
Developmental biology
Enhancers
Epigenetics
Embryogenesis
Cell fate
Multi-omics
Online Access:https://doi.org/10.1186/s13059-025-03658-8
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https://doi.org/10.1186/s13059-025-03658-8

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