Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages and disadvantages in terms of developability, immunogenic...

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Bibliographic Details
Main Authors: Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
CHO cell
avidity
bispecific antibody
functionality
manufacturability
targeted integration
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2231129
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https://www.tandfonline.com/doi/10.1080/19420862.2023.2231129

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