Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD

Abstract Genetic mutations in the progranulin gene, GRN, cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant (GRN+/−) carriers we find dysregulation of microglia, phagoc...

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Main Authors: Claire Dudley Clelland, Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad Richard Altobelli, Sally Salomonsson, Alisha M. Maltos, Aradhana Sachdev, Jingjie Zhu, Se-In Lee, Yaqiao Li, Yungui Zhou, David Le, Chao Wang, Gillian Carling, Lay Kodama, Faten Sayed, Jaun A. Perez-Bermejo, Ethan G. Geier, Jennifer S. Yokoyama, Howie Rosen, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Fanny Elahi, Adam L. Boxer, Michelle R. Arkin, Li Gan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08368-2
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https://doi.org/10.1038/s42003-025-08368-2

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