Identification of Dinaciclib and Ganetespib as anti-inflammatory drugs using a novel HTP screening assay that targets IFNγ-dependent PD-L1

Identification of Dinaciclib and Ganetespib as anti-inflammatory drugs using a novel HTP screening assay that targets IFNγ-dependent PD-L1

IntroductionIFNγ plays both positive and negative roles in the regulation of innate and adaptive immune responses against tumors and virally infected tissues by upregulating CXCL10 and PD-L1 expression.MethodsTo identify novel pathways and drugs that regulate the IFNγ-dependent PD-L1, we expressed G...

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Bibliographic Details
Main Authors: Shira Hagbi-Levi, Michal Abraham, Lika Gamaev, Inbal Mishaelian, Ophir Hay, Elina Zorde-Khevalevsky, Ori Wald, Hanna Wald, Devorah Olam, Lola Weiss, Amnon Peled
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
IFNγ
PD-L1
CXCL10
immunotherapy
cancer
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1502094/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1502094/full

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