QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration
Abstract DNA methylation provides a crucial epigenetic mark linking genetic variations to environmental influence. We have analyzed array-based DNA methylation profiles of 160 human retinas with co-measured RNA-seq and >8 million genetic variants, uncovering sites of genetic regulation in cis (37...
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Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-46063-8 |
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