Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia
Inflammation characterizes the course of acute and chronic diseases and is largely responsible for the metabolic and behavioral changes occurring during the clinical journey of patients. Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostas...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/801685 |
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| _version_ | 1832549112663244800 |
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| author | Alessio Molfino Gianfranco Gioia Filippo Rossi Fanelli Alessandro Laviano |
| author_facet | Alessio Molfino Gianfranco Gioia Filippo Rossi Fanelli Alessandro Laviano |
| author_sort | Alessio Molfino |
| collection | DOAJ |
| description | Inflammation characterizes the course of acute and chronic diseases and is largely responsible for the metabolic and behavioral changes occurring during the clinical journey of patients. Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue. In particular, functional changes are associated with increased hypothalamic concentration of proinflammatory cytokines, which suggests that neuroinflammation may represent the adaptive response of the brain to peripheral challenges, including tumor growth. Within this conceptual framework, the vagus nerve appears to be involved in conveying alert signals to the hypothalamus, whereas hypothalamic serotonin appears to contribute to triggering catabolic signals. |
| format | Article |
| id | doaj-art-8d2bc3eca4f841b0999ed506074d7978 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8d2bc3eca4f841b0999ed506074d79782025-02-03T06:12:09ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/801685801685Contribution of Neuroinflammation to the Pathogenesis of Cancer CachexiaAlessio Molfino0Gianfranco Gioia1Filippo Rossi Fanelli2Alessandro Laviano3Department of Clinical Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Clinical Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Clinical Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Clinical Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyInflammation characterizes the course of acute and chronic diseases and is largely responsible for the metabolic and behavioral changes occurring during the clinical journey of patients. Robust data indicate that, during cancer, functional modifications within brain areas regulating energy homeostasis contribute to the onset of anorexia, reduced food intake, and increased catabolism of muscle mass and adipose tissue. In particular, functional changes are associated with increased hypothalamic concentration of proinflammatory cytokines, which suggests that neuroinflammation may represent the adaptive response of the brain to peripheral challenges, including tumor growth. Within this conceptual framework, the vagus nerve appears to be involved in conveying alert signals to the hypothalamus, whereas hypothalamic serotonin appears to contribute to triggering catabolic signals.http://dx.doi.org/10.1155/2015/801685 |
| spellingShingle | Alessio Molfino Gianfranco Gioia Filippo Rossi Fanelli Alessandro Laviano Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia Mediators of Inflammation |
| title | Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia |
| title_full | Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia |
| title_fullStr | Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia |
| title_full_unstemmed | Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia |
| title_short | Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia |
| title_sort | contribution of neuroinflammation to the pathogenesis of cancer cachexia |
| url | http://dx.doi.org/10.1155/2015/801685 |
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