Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature
Introduction. Parathyroid carcinoma is one of the rarest cancers in normal population, and it is extremely uncommon in the setting of tertiary hyperparathyroidism. Indeed, only 24 cases have been reported in the literature. Presentation of the Case. We report the case of parathyroid carcinoma in a 5...
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/5710468 |
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| author | Federico Cappellacci Fabio Medas Gian Luigi Canu Maria Letizia Lai Giovanni Conzo Enrico Erdas Pietro Giorgio Calò |
| author_facet | Federico Cappellacci Fabio Medas Gian Luigi Canu Maria Letizia Lai Giovanni Conzo Enrico Erdas Pietro Giorgio Calò |
| author_sort | Federico Cappellacci |
| collection | DOAJ |
| description | Introduction. Parathyroid carcinoma is one of the rarest cancers in normal population, and it is extremely uncommon in the setting of tertiary hyperparathyroidism. Indeed, only 24 cases have been reported in the literature. Presentation of the Case. We report the case of parathyroid carcinoma in a 51-year-old man, with a history of end-stage renal disease due to a horseshoe kidney treated with haemodialysis since 2013. He came to our attention due to an increase in calcium and parathyroid hormone serum levels. Neck ultrasound (US) showed a solid hypodense mass, probably the right inferior parathyroid gland, with an estimated size of 25 × 15 × 13 mm; the 99mTc-sestamibi SPECT/CT scan revealed a large radiotracer activity area in the right cervical region, compatible with a hyperfunctioning right inferior parathyroid gland. So, a tertiary hyperparathyroidism diagnosis was made. In April 2018, resection of three parathyroid glands was performed. Histopathological examination demonstrated the right inferior parathyroid gland specimen to be a parathyroid carcinoma, due to the presence of multiple, full-thickness, capsular infiltration foci, and a venous vascular invasion focus. Discussion. Diagnosis of parathyroid carcinoma in tertiary hyperparathyroidism is remarkably complex because of the lack of clinical diagnostic criteria and, in many cases, is made postoperatively at histopathological examination. Conclusion. To date, radical surgery represents the mainstay of treatment, with a five- and ten-year survival rates overall acceptable. |
| format | Article |
| id | doaj-art-8d05970dd4f44294876a03e074e91753 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-8d05970dd4f44294876a03e074e917532025-02-03T05:51:16ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/57104685710468Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the LiteratureFederico Cappellacci0Fabio Medas1Gian Luigi Canu2Maria Letizia Lai3Giovanni Conzo4Enrico Erdas5Pietro Giorgio Calò6Department of Surgical Sciences, University of Cagliari, “Policlinico Universitario Duilio Casula”, 09042 Monserrato, ItalyDepartment of Surgical Sciences, University of Cagliari, “Policlinico Universitario Duilio Casula”, 09042 Monserrato, ItalyDepartment of Surgical Sciences, University of Cagliari, “Policlinico Universitario Duilio Casula”, 09042 Monserrato, ItalyDepartment of Cytomorphology, University of Cagliari, Cagliari, ItalyDivision of Medical Oncology, Department of Internal and Experimental Medicine “F. Magrassi”, School of Medicine, University of Campania “Luigi Vanvitelli”, Cagliari, ItalyDepartment of Surgical Sciences, University of Cagliari, “Policlinico Universitario Duilio Casula”, 09042 Monserrato, ItalyDepartment of Surgical Sciences, University of Cagliari, “Policlinico Universitario Duilio Casula”, 09042 Monserrato, ItalyIntroduction. Parathyroid carcinoma is one of the rarest cancers in normal population, and it is extremely uncommon in the setting of tertiary hyperparathyroidism. Indeed, only 24 cases have been reported in the literature. Presentation of the Case. We report the case of parathyroid carcinoma in a 51-year-old man, with a history of end-stage renal disease due to a horseshoe kidney treated with haemodialysis since 2013. He came to our attention due to an increase in calcium and parathyroid hormone serum levels. Neck ultrasound (US) showed a solid hypodense mass, probably the right inferior parathyroid gland, with an estimated size of 25 × 15 × 13 mm; the 99mTc-sestamibi SPECT/CT scan revealed a large radiotracer activity area in the right cervical region, compatible with a hyperfunctioning right inferior parathyroid gland. So, a tertiary hyperparathyroidism diagnosis was made. In April 2018, resection of three parathyroid glands was performed. Histopathological examination demonstrated the right inferior parathyroid gland specimen to be a parathyroid carcinoma, due to the presence of multiple, full-thickness, capsular infiltration foci, and a venous vascular invasion focus. Discussion. Diagnosis of parathyroid carcinoma in tertiary hyperparathyroidism is remarkably complex because of the lack of clinical diagnostic criteria and, in many cases, is made postoperatively at histopathological examination. Conclusion. To date, radical surgery represents the mainstay of treatment, with a five- and ten-year survival rates overall acceptable.http://dx.doi.org/10.1155/2020/5710468 |
| spellingShingle | Federico Cappellacci Fabio Medas Gian Luigi Canu Maria Letizia Lai Giovanni Conzo Enrico Erdas Pietro Giorgio Calò Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature Case Reports in Endocrinology |
| title | Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature |
| title_full | Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature |
| title_fullStr | Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature |
| title_full_unstemmed | Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature |
| title_short | Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature |
| title_sort | parathyroid carcinoma in the setting of tertiary hyperparathyroidism case report and review of the literature |
| url | http://dx.doi.org/10.1155/2020/5710468 |
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