Cellular SLC35B4 promotes internalization during influenza A virus entry

Cellular SLC35B4 promotes internalization during influenza A virus entry

ABSTRACT SLC35B4, a nucleotide sugar transporter that mediates the transport of UDP-GlcNAc and UDP-xylose, was found to be required for the replication of influenza A virus (IAV) of the H5N1 subtype in our genome-wide siRNA library screen. We found that defective IAV replication in SLC35B4-deficient...

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Main Authors: Guangwen Wang, Li Jiang, Ya Yan, Fandi Kong, Qibing Li, Jie Zhang, Shuangshuang Hou, Bo Wang, Xiurong Wang, Huihui Kong, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Hualan Chen, Chengjun Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
influenza A virus
internalization
SLC35B4
AGRN
heparan sulfate modification
AP2B1
Online Access:https://journals.asm.org/doi/10.1128/mbio.00194-25
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https://journals.asm.org/doi/10.1128/mbio.00194-25

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