Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives
A series of porphyrin derivatives 2a–f was synthesized, namely, 5,10,15,20-mesotetrakis[p-methoxyphenyl]-21H,23H-porphyrin (2a), 5,10,15,20-mesotetrakis[2,6-dichloro-phenyl]-21H,23H-porphyrin (2b), 5,10,15,20-mesotetrakis[4-hydroxy-3,5-dimethoxyphenyl]-21H,23H-porphyrin (2c), 5,10,15,20-mesotetrakis...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/340230 |
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| author | Ahmed A. Fadda Rasha E. El-Mekawy Ahmed El-Shafei Harold S. Freeman David Hinks Manal El-Fedawy |
| author_facet | Ahmed A. Fadda Rasha E. El-Mekawy Ahmed El-Shafei Harold S. Freeman David Hinks Manal El-Fedawy |
| author_sort | Ahmed A. Fadda |
| collection | DOAJ |
| description | A series of porphyrin derivatives 2a–f was synthesized, namely, 5,10,15,20-mesotetrakis[p-methoxyphenyl]-21H,23H-porphyrin (2a), 5,10,15,20-mesotetrakis[2,6-dichloro-phenyl]-21H,23H-porphyrin (2b), 5,10,15,20-mesotetrakis[4-hydroxy-3,5-dimethoxyphenyl]-21H,23H-porphyrin (2c), 5,10,15,20-mesotetrakis[3,4-dimethoxyphenyl]-21H,23H-porphyrin (2d), 5,10,15,20-mesotetrakis[2,4-dichlorophenyl]-21H,23H-porphyrin (2e), and 5,10,15,20-mesotetrakis[3,4,5-trimethoxyphenyl]-21H,23H-porphyrin (2f), in high yields using a new method via a capping mechanism. These dyes were used as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. It was demonstrated that these dyes were effective in the inhibition of the free radical-induced oxidative haemolysis of rat blood cells. Dyes 2d and 2f which bear methoxy functionality exhibited markedly higher antihaemolysis activity than the other analogs. Molecular modeling methods using ZINDO/INDO-1, with a configuration interaction of 26, and TD-DFT using the energy functional B3LYP and the basis set DGTZVP were used to study the vertical electronic excitations of porphyrins 2a–f and it was shown that the
calculated using TD-DFT method was in excellent agreement with the experimental results, while the ZINDO method was inferior. Moreover, excellent correlation between the LUMO energy and cytotoxicity of dyes 2a–f was found. |
| format | Article |
| id | doaj-art-8cb5f7588ecc4f10a223f98e2d297bdf |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-8cb5f7588ecc4f10a223f98e2d297bdf2025-02-03T06:13:15ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/340230340230Design, Synthesis, and Pharmacological Screening of Novel Porphyrin DerivativesAhmed A. Fadda0Rasha E. El-Mekawy1Ahmed El-Shafei2Harold S. Freeman3David Hinks4Manal El-Fedawy5Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, EgyptDepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, EgyptPolymer and Color Chemistry Program, North Carolina State University, Raleigh, NC 27695, USAPolymer and Color Chemistry Program, North Carolina State University, Raleigh, NC 27695, USAPolymer and Color Chemistry Program, North Carolina State University, Raleigh, NC 27695, USADepartment of Chemistry, Faculty of Science, Mansoura University, Mansoura, EgyptA series of porphyrin derivatives 2a–f was synthesized, namely, 5,10,15,20-mesotetrakis[p-methoxyphenyl]-21H,23H-porphyrin (2a), 5,10,15,20-mesotetrakis[2,6-dichloro-phenyl]-21H,23H-porphyrin (2b), 5,10,15,20-mesotetrakis[4-hydroxy-3,5-dimethoxyphenyl]-21H,23H-porphyrin (2c), 5,10,15,20-mesotetrakis[3,4-dimethoxyphenyl]-21H,23H-porphyrin (2d), 5,10,15,20-mesotetrakis[2,4-dichlorophenyl]-21H,23H-porphyrin (2e), and 5,10,15,20-mesotetrakis[3,4,5-trimethoxyphenyl]-21H,23H-porphyrin (2f), in high yields using a new method via a capping mechanism. These dyes were used as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. It was demonstrated that these dyes were effective in the inhibition of the free radical-induced oxidative haemolysis of rat blood cells. Dyes 2d and 2f which bear methoxy functionality exhibited markedly higher antihaemolysis activity than the other analogs. Molecular modeling methods using ZINDO/INDO-1, with a configuration interaction of 26, and TD-DFT using the energy functional B3LYP and the basis set DGTZVP were used to study the vertical electronic excitations of porphyrins 2a–f and it was shown that the calculated using TD-DFT method was in excellent agreement with the experimental results, while the ZINDO method was inferior. Moreover, excellent correlation between the LUMO energy and cytotoxicity of dyes 2a–f was found.http://dx.doi.org/10.1155/2013/340230 |
| spellingShingle | Ahmed A. Fadda Rasha E. El-Mekawy Ahmed El-Shafei Harold S. Freeman David Hinks Manal El-Fedawy Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives Journal of Chemistry |
| title | Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives |
| title_full | Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives |
| title_fullStr | Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives |
| title_full_unstemmed | Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives |
| title_short | Design, Synthesis, and Pharmacological Screening of Novel Porphyrin Derivatives |
| title_sort | design synthesis and pharmacological screening of novel porphyrin derivatives |
| url | http://dx.doi.org/10.1155/2013/340230 |
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