转运RNA衍生片段在甲状腺癌发病机制中的作用

目的探讨tRNA衍生片段(tRFs)<italic>3'tiR_026_GlnCTG </italic>(<italic>n</italic>)在甲状腺乳头状癌(PTC)中的表达及其致癌机制。方法首先取2对PTC和邻近正常甲状腺组织用于高通量芯片检测,筛选差异tRFs。在芯片结果基础上,我们在10对PTC和邻近正常甲状腺组织中验证了差异明显的tRNA衍生片段的表达。接着扩大样本量,继续收集共46例患者的PTC和邻近正常甲状腺组织,通过定量聚合酶链反应(qPCR)验证<italic>3'tiR_026_GlnCTG...

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Bibliographic Details
Main Authors: 彭妙官, 赖英荣
Format: Article
Language:zho
Published: Editorial Office of Journal of Sun Yat-sen University 2022-05-01
Series:Zhongshan Daxue xuebao. Yixue kexue ban
Subjects:
Online Access:http://xuebaoyx.sysu.edu.cn/zh/article/doi/10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2022.0312/
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