The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells

The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells

Abstract Background A dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP1) receptor agonist, tirzepatide (TZPD), is a novel cardioprotective agent, particularly in metabolic disturbances-related co-morbidities, however, there is no exact study to emphasize its p...

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Main Authors: Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cardiovascular Diabetology
Online Access:https://doi.org/10.1186/s12933-025-02828-z
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https://doi.org/10.1186/s12933-025-02828-z

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