Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity.

The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the histone methyltransferase Trithorax (Trx) is required in postmitotic memory neurons of the Drosophila mushroom body (MB) to enable their capacity for long-t...

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Bibliographic Details
Main Authors: Nicholas Raun, Spencer G Jones, Olivia Kerr, Crystal Keung, Emily F Butler, Kumari Alka, Jonathan D Krupski, Robert A Reid-Taylor, Veyan Ibrahim, MacKayla Williams, Deniz Top, Jamie M Kramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003004
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