Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer

Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer

Abstract Hypoxia-inducible factors (HIFs) are essential transcription factors that orchestrate cellular responses to oxygen deprivation. HIF-1α, as an unstable subunit of HIF-1, is usually hydroxylated by prolyl hydroxylase domain enzymes under normoxic conditions, leading to ubiquitination and prot...

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Bibliographic Details
Main Authors: Jiayi Zhang, Mingxuan Yao, Shiting Xia, Fancai Zeng, Qiuyu Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
HIF-1
Normoxia
Pseudohypoxia
Mechanisms
Cancer
Cellular response
Online Access:https://doi.org/10.1186/s11658-024-00682-7
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https://doi.org/10.1186/s11658-024-00682-7

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