Periconceptional Folate Deficiency and Implications in Neural Tube Defects
Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/295083 |
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| author | J. Safi L. Joyeux G. E. Chalouhi |
| author_facet | J. Safi L. Joyeux G. E. Chalouhi |
| author_sort | J. Safi |
| collection | DOAJ |
| description | Nutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medical literature about folate deficiency, be it maternal or paternal. It then focuses on associated deficiencies as nutritional deficiencies are multiple and interrelated. Observational and interventional studies have all been consistent with a 50–70% protective effect of adequate women consumption of folates on neural tube defects. Since strategies to modify women’s dietary habits and vitamin use have achieved little progress, scientific as well as political effort is mandatory in order to implement global preventive public health strategies aimed at improving the alimentation of women in reproductive age, especially folic acid supplementation. Even with the recent breakthrough of fetal surgery for myelomeningocele, the emphasis should still be on prevention as the best practice rather than treatment of neural tube defects. |
| format | Article |
| id | doaj-art-8c4fbcd5a86547048a8fcb016e95635d |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-8c4fbcd5a86547048a8fcb016e95635d2025-02-03T01:12:06ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/295083295083Periconceptional Folate Deficiency and Implications in Neural Tube DefectsJ. Safi0L. Joyeux1G. E. Chalouhi2Department of Obstetrics and Gynecology, St Joseph University, Hôtel-Dieu de France, 1100 Beirut, LebanonDepartment of Pediatric Surgery, Children’s Hospital of Dijon, University Medical Center, 21000 Dijon, FranceDepartment of Obstetrics and Fetal Medicine, Hôpital Necker-Enfants-Malades, Paris Descartes University, Assistance Publique-Hôpitaux de Paris, 75015 Paris, FranceNutritional deficiencies are preventable etiological and epigenetic factors causing congenital abnormalities, first cause of infant mortality. Folate deficiency has a well-established teratogenic effect, leading to an increasing risk of neural tube defects. This paper highlights the most recent medical literature about folate deficiency, be it maternal or paternal. It then focuses on associated deficiencies as nutritional deficiencies are multiple and interrelated. Observational and interventional studies have all been consistent with a 50–70% protective effect of adequate women consumption of folates on neural tube defects. Since strategies to modify women’s dietary habits and vitamin use have achieved little progress, scientific as well as political effort is mandatory in order to implement global preventive public health strategies aimed at improving the alimentation of women in reproductive age, especially folic acid supplementation. Even with the recent breakthrough of fetal surgery for myelomeningocele, the emphasis should still be on prevention as the best practice rather than treatment of neural tube defects.http://dx.doi.org/10.1155/2012/295083 |
| spellingShingle | J. Safi L. Joyeux G. E. Chalouhi Periconceptional Folate Deficiency and Implications in Neural Tube Defects Journal of Pregnancy |
| title | Periconceptional Folate Deficiency and Implications in Neural Tube Defects |
| title_full | Periconceptional Folate Deficiency and Implications in Neural Tube Defects |
| title_fullStr | Periconceptional Folate Deficiency and Implications in Neural Tube Defects |
| title_full_unstemmed | Periconceptional Folate Deficiency and Implications in Neural Tube Defects |
| title_short | Periconceptional Folate Deficiency and Implications in Neural Tube Defects |
| title_sort | periconceptional folate deficiency and implications in neural tube defects |
| url | http://dx.doi.org/10.1155/2012/295083 |
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