DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica—trial protocol

DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica—trial protocol

Introduction Sciatica is a debilitating condition that often becomes chronic, and for which there are few effective treatment options. Treatments such as the anti-depressant duloxetine have shown promise, but the evidence is inconclusive. We are describing a high quality, definitive trial to investi...

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Main Authors: Martin Underwood, Chung-Wei Christine Lin, Bethan Richards, Michael Dinh, Ralph Stanford, Christopher G Maher, Andrew J McLachlan, Thomas Lung, Peter Youssef, Laurent Billot, James McAuley, Giovanni E Ferreira, Richard O Day, Rowena Ivers, Melanie Hamilton, Ralph Audehm, Christopher Needs, Nanna B Finnerup, Monika Boogs, Melissa Webb, Hanan McLachlan, Nanna Finnerup, Ananthila Anandacoomarasamy, Masoud Jamshidi, Kate Tong
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/14/12/e096796.full
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https://bmjopen.bmj.com/content/14/12/e096796.full

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