MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models
We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were sign...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/954548 |
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| author | Beatriz Aparecida Fioruci-Fontanelli Luiz Gustavo A. Chuffa Leonardo O. Mendes Patricia Fernanda F. Pinheiro Flávia Karina Delella Cilmery S. Kurokawa Sérgio Luis Felisbino Francisco Eduardo Martinez |
| author_facet | Beatriz Aparecida Fioruci-Fontanelli Luiz Gustavo A. Chuffa Leonardo O. Mendes Patricia Fernanda F. Pinheiro Flávia Karina Delella Cilmery S. Kurokawa Sérgio Luis Felisbino Francisco Eduardo Martinez |
| author_sort | Beatriz Aparecida Fioruci-Fontanelli |
| collection | DOAJ |
| description | We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. Dorsal prostatic lobe was less affected showing no significant alterations in these proteins, except for a reduction in the TIMP-1 expression in UChA rats. These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases. Furthermore, since these proteins are also components of prostate secretion, the negative impact of chronic ethanol intake on fertility may also involve reduction of MMPs and TIMPs in the seminal fluid. |
| format | Article |
| id | doaj-art-8c37e3b8ceb34dbfb06ea947df1ecb40 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-8c37e3b8ceb34dbfb06ea947df1ecb402025-02-03T05:49:29ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/954548954548MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat ModelsBeatriz Aparecida Fioruci-Fontanelli0Luiz Gustavo A. Chuffa1Leonardo O. Mendes2Patricia Fernanda F. Pinheiro3Flávia Karina Delella4Cilmery S. Kurokawa5Sérgio Luis Felisbino6Francisco Eduardo Martinez7Department of Anatomy, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Anatomy, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Anatomy, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Anatomy, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Morphology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Pediatrics, Faculty of Medicine, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Morphology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Anatomy, Institute of Biosciences, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilWe investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals. Dorsal prostatic lobe was less affected showing no significant alterations in these proteins, except for a reduction in the TIMP-1 expression in UChA rats. These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases. Furthermore, since these proteins are also components of prostate secretion, the negative impact of chronic ethanol intake on fertility may also involve reduction of MMPs and TIMPs in the seminal fluid.http://dx.doi.org/10.1155/2015/954548 |
| spellingShingle | Beatriz Aparecida Fioruci-Fontanelli Luiz Gustavo A. Chuffa Leonardo O. Mendes Patricia Fernanda F. Pinheiro Flávia Karina Delella Cilmery S. Kurokawa Sérgio Luis Felisbino Francisco Eduardo Martinez MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models Analytical Cellular Pathology |
| title | MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models |
| title_full | MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models |
| title_fullStr | MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models |
| title_full_unstemmed | MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models |
| title_short | MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models |
| title_sort | mmp 2 and mmp 9 activities and timp 1 and timp 2 expression in the prostatic tissue of two ethanol preferring rat models |
| url | http://dx.doi.org/10.1155/2015/954548 |
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