Liposome nano‐formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH‐responsive carrier for molecular therapeutic drug (all‐trans retinoic acid) delivery to lung cancer cells

Liposome nano‐formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH‐responsive carrier for molecular therapeutic drug (all‐trans retinoic acid) delivery to lung cancer cells

Abstract The molecular targeted drug ATRA demands a suitable carrier that delivers to the cancer site due to its poor bioavailability and drug resistance. ATRA, being a lipid with carboxylic acid, has been nano‐formulated as a cationic lipo‐ATRA with DOTAP:cholesterol:ATRA (5:4:1) and its pH‐respons...

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Bibliographic Details
Main Authors: Viswanathan Mariammal Berlin Grace, Devarajan David Wilson, Chandrasekharan Guruvayoorappan, Jesubatham Perinba Danisha, Lucia Bonati
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:IET Nanobiotechnology
Subjects:
biochemistry
biomedical materials
cancer
cellular biophysics
drug delivery systems
drugs
Online Access:https://doi.org/10.1049/nbt2.12028
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https://doi.org/10.1049/nbt2.12028

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