The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach
The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/954045 |
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| author | Bulent Demir Esra Demir Gonul Acıksarı Turgut Uygun Irem Kırac Utku Asuman Gedikbasi Ilker Murat Caglar Osman Pirhan Hande Oktay Tureli Ersan Oflar İsmail Ungan Serkan Ciftci Osman Karakaya |
| author_facet | Bulent Demir Esra Demir Gonul Acıksarı Turgut Uygun Irem Kırac Utku Asuman Gedikbasi Ilker Murat Caglar Osman Pirhan Hande Oktay Tureli Ersan Oflar İsmail Ungan Serkan Ciftci Osman Karakaya |
| author_sort | Bulent Demir |
| collection | DOAJ |
| description | The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 ± 2.0 mm and 4.0 ± 1.0 mm, resp.; P<0.001). The level of TOS was higher in the MeS group compared to the control group (P<0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P<0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P<0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS. |
| format | Article |
| id | doaj-art-8c2037ccba6041acad2858dde73477cc |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8c2037ccba6041acad2858dde73477cc2025-02-03T06:44:47ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/954045954045The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker ApproachBulent Demir0Esra Demir1Gonul Acıksarı2Turgut Uygun3Irem Kırac Utku4Asuman Gedikbasi5Ilker Murat Caglar6Osman Pirhan7Hande Oktay Tureli8Ersan Oflar9İsmail Ungan10Serkan Ciftci11Osman Karakaya12Department of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, TurkeyDepartment of Cardiology, İstinye State Hospital, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of İnternal Medicine, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, TurkeyDepartment of Biochemistry, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyDepartment of Cardiology, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Tevfik Sağlam Caddesi No. 11, Zuhuratbaba Mahallesi, Bakırköy, 34156 Istanbul, TurkeyThe risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 ± 2.0 mm and 4.0 ± 1.0 mm, resp.; P<0.001). The level of TOS was higher in the MeS group compared to the control group (P<0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P<0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P<0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.http://dx.doi.org/10.1155/2014/954045 |
| spellingShingle | Bulent Demir Esra Demir Gonul Acıksarı Turgut Uygun Irem Kırac Utku Asuman Gedikbasi Ilker Murat Caglar Osman Pirhan Hande Oktay Tureli Ersan Oflar İsmail Ungan Serkan Ciftci Osman Karakaya The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach International Journal of Endocrinology |
| title | The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach |
| title_full | The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach |
| title_fullStr | The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach |
| title_full_unstemmed | The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach |
| title_short | The Association between the Epicardial Adipose Tissue Thickness and Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A Multimarker Approach |
| title_sort | association between the epicardial adipose tissue thickness and oxidative stress parameters in isolated metabolic syndrome patients a multimarker approach |
| url | http://dx.doi.org/10.1155/2014/954045 |
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