Erythropoietin delivery through kidney organoids engineered with an episomal DNA vector

Erythropoietin delivery through kidney organoids engineered with an episomal DNA vector

Abstract Background The kidney’s endocrine function is essential for maintaining body homeostasis. Erythropoietin (EPO) is one of the key endocrine factors produced by the kidney, and kidney disease patients frequently experience anemia due to impaired EPO production. In the present study we explore...

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Main Authors: Z. Du, A. Bas-Cristóbal Menéndez, M. Urban, A. Hartley, D. Ratsma, M. Koedam, T. P.P. van den Bosch, M. Clahsen-van Groningen, J. Gribnau, J. Mulder, M. E.J. Reinders, C. C. Baan, B. van der Eerden, R. P. Harbottle, Martin J. Hoogduijn
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
DNA vector
Erythropoietin
Kidney
Organoids
Pluripotent stem cells
Online Access:https://doi.org/10.1186/s13287-025-04282-w
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https://doi.org/10.1186/s13287-025-04282-w

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