Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages

Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages

Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem. The Mhem phenotype expresses elevated levels of hemoglobin (Hb) scavenger receptor, CD163, capable of endocytosing pro-oxidant free Hb...

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Bibliographic Details
Main Authors:	R. Clive Landis, Pandelis Philippidis, Jan Domin, Joseph J. Boyle, Dorian O. Haskard
Format:	Article
Language:	English
Published:	Wiley 2013-01-01
Series:	International Journal of Inflammation
Online Access:	http://dx.doi.org/10.1155/2013/980327
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