Deciphering the Structural and Functional Paradigms of <i>Clostridioides difficile</i> Toxins TcdA and TcdB

Deciphering the Structural and Functional Paradigms of <i>Clostridioides difficile</i> Toxins TcdA and TcdB

<i>Clostridioides difficile</i> Infection (CDI) continues to be a major cause of antibiotic-associated diarrhea and pseudomembranous colitis, fueled in large measure by virulence factors TcdA and TcdB. These giant glucosyltransferase toxins interfere with host cytoskeletal integrity and...

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Bibliographic Details
Main Authors:	Mohammad Qutub, Amol Tatode, Ujban Md Hussain, Tanvi Premchandani, Jayshree Taksande, Milind Umekar, Deepak Thakre
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Series:	Bacteria
Subjects:	<i>C. difficile</i> toxins toxin structure–function Rho GTPase glucosylation host–pathogen interactions inflammasome activation CRISPR-based therapeutics
Online Access:	https://www.mdpi.com/2674-1334/4/2/21
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