Deciphering the Structural and Functional Paradigms of <i>Clostridioides difficile</i> Toxins TcdA and TcdB

Deciphering the Structural and Functional Paradigms of <i>Clostridioides difficile</i> Toxins TcdA and TcdB

<i>Clostridioides difficile</i> Infection (CDI) continues to be a major cause of antibiotic-associated diarrhea and pseudomembranous colitis, fueled in large measure by virulence factors TcdA and TcdB. These giant glucosyltransferase toxins interfere with host cytoskeletal integrity and...

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Bibliographic Details
Main Authors: Mohammad Qutub, Amol Tatode, Ujban Md Hussain, Tanvi Premchandani, Jayshree Taksande, Milind Umekar, Deepak Thakre
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Bacteria
Subjects:
<i>C. difficile</i> toxins
toxin structure–function
Rho GTPase glucosylation
host–pathogen interactions
inflammasome activation
CRISPR-based therapeutics
Online Access:https://www.mdpi.com/2674-1334/4/2/21
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https://www.mdpi.com/2674-1334/4/2/21

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