Molecular networking derived from untargeted LC-MS/MS analysis to discover inhibitors of RANKL-induced osteoclastogenesis from Egyptian marine sponge-associated fungi

Molecular networking derived from untargeted LC-MS/MS analysis to discover inhibitors of RANKL-induced osteoclastogenesis from Egyptian marine sponge-associated fungi

Abstract In continuous search for RANKL induced osteoclastogenesis inhibitors, twenty-six fungal isolates were obtained from ten Red Sea marine sponges collected from Egypt and the ethyl acetate fractions of their cultures’ methanol extracts were assessed in RAW264 macrophages. Active fractions were...

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Bibliographic Details
Main Authors: Abdelhalim A. Elgahamy, Ahmed H. El-Desoky, Asmaa M. Otify, Ahlam M. El Fishawy, Ahmed A. El-Beih
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bisphenols
Osteoclastogenesis
Aspergillus flavus
Metabolomics
Cladosporium
Online Access:https://doi.org/10.1038/s41598-025-12456-y
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https://doi.org/10.1038/s41598-025-12456-y

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