Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation

Aim There remain limited therapies to treat thyroid eye disease (TED) orbital fibrosis, highlighting the urgency to develop novel targets. Transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from orbital fibroblasts are important pathogenetic factor of TED. Endoplasmic...

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Bibliographic Details
Main Authors: Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:BMJ Open Ophthalmology
Online Access:https://bmjophth.bmj.com/content/9/1/e001693.full
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