Pathological Significance of Mitochondrial Glycation
Glycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing. Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation. Because these dicarbonyls tend to be formed intracellularly, the levels...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/843505 |
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| author | Pamela Boon Li Pun Michael P. Murphy |
| author_facet | Pamela Boon Li Pun Michael P. Murphy |
| author_sort | Pamela Boon Li Pun |
| collection | DOAJ |
| description | Glycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing. Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation. Because these dicarbonyls tend to be formed intracellularly, the levels of advanced glycation end products on cellular proteins are higher than on extracellular ones. The formation of glycation adducts within cells can have severe functional consequences such as inhibition of protein activity and promotion of DNA mutations. Although several lines of evidence suggest that there are specific mitochondrial targets of glycation, and mitochondrial dysfunction itself has been implicated in disease and ageing, it is unclear if glycation of biomolecules specifically within mitochondria induces dysfunction and contributes to disease pathology. We discuss here the possibility that mitochondrial glycation contributes to disease, focussing on diabetes, ageing, cancer, and neurodegeneration, and highlight the current limitations in our understanding of the pathological significance of mitochondrial glycation. |
| format | Article |
| id | doaj-art-8bb7558f6b104a33b46f9c6d42db39df |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-8bb7558f6b104a33b46f9c6d42db39df2025-02-03T07:26:15ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/843505843505Pathological Significance of Mitochondrial GlycationPamela Boon Li Pun0Michael P. Murphy1MRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UKMRC Mitochondrial Biology Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, UKGlycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing. Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation. Because these dicarbonyls tend to be formed intracellularly, the levels of advanced glycation end products on cellular proteins are higher than on extracellular ones. The formation of glycation adducts within cells can have severe functional consequences such as inhibition of protein activity and promotion of DNA mutations. Although several lines of evidence suggest that there are specific mitochondrial targets of glycation, and mitochondrial dysfunction itself has been implicated in disease and ageing, it is unclear if glycation of biomolecules specifically within mitochondria induces dysfunction and contributes to disease pathology. We discuss here the possibility that mitochondrial glycation contributes to disease, focussing on diabetes, ageing, cancer, and neurodegeneration, and highlight the current limitations in our understanding of the pathological significance of mitochondrial glycation.http://dx.doi.org/10.1155/2012/843505 |
| spellingShingle | Pamela Boon Li Pun Michael P. Murphy Pathological Significance of Mitochondrial Glycation International Journal of Cell Biology |
| title | Pathological Significance of Mitochondrial Glycation |
| title_full | Pathological Significance of Mitochondrial Glycation |
| title_fullStr | Pathological Significance of Mitochondrial Glycation |
| title_full_unstemmed | Pathological Significance of Mitochondrial Glycation |
| title_short | Pathological Significance of Mitochondrial Glycation |
| title_sort | pathological significance of mitochondrial glycation |
| url | http://dx.doi.org/10.1155/2012/843505 |
| work_keys_str_mv | AT pamelaboonlipun pathologicalsignificanceofmitochondrialglycation AT michaelpmurphy pathologicalsignificanceofmitochondrialglycation |