The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancerResearch in context

The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancerResearch in context

Summary: Background: Approximately 10% of cases with gastric cancer (GC) exhibit familial clustering, however, only 1–3% of cases can be explained by two known hereditary syndromes: Hereditary Diffuse Gastric Cancer (HDGC) caused by CDH1 and CTNNA1 pathogenic germline variants; and Gastric Adenocar...

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Main Authors: Joana Guerra, Ana P. Estrada-Florez, Paul C. Lott, Carla Pinto, Manuela Pinheiro, Katherine A. Chiu, Dennis J. Montoya, Hongyong Zhang, Guadalupe M. Polanco-Echeverry, Pedro Pinto, Ana Peixoto, Catarina Santos, Ana Barbosa, João Silva, John Suarez-Olaya, Fabian Castro-Valencia, Graciela Molina, Alejandro H. Corvalán, Adriana Della Valle, Jose E. Castelao, Nereida Fernandez-Fernandez, Lucia Cid, Nora Rios-Sarabia, Rafael Medrano, Alejandra Mantilla, Maria M. Echeverry de Polanco, Ana L. Rivera-Herrera, Julián Riaño-Moreno, Rafael Parra-Medina, Luz M. González-Castrillón, Ricardo Dominguez, Ana R. Isidoro, Fernanda Silva, Douglas R. Morgan, Alicia M. Cock-Rada, Maria C. Sanabria-Salas, Mabel H. Bohorquez, Javier Torres, Manuel R. Teixeira, Luis G. Carvajal-Carmona, Hernandez Vicent, Alonso Sara, Galovart Miguel, Rodriguez-D'Jesus Antonio, de Castro Luisa, Rodriguez-Prada José Ignacio, Gago-Domínguez Manuela, Redondo-Marey Carmen, Miranda Ponte Sara, González Patricio, Parra Carol, Torres Osvaldo, Adelsdorfer Cedric, Martínez Jose, Norwood Dalton, Montalvan-Sanchez Eleazar, Nefa Florencia, Sanchez Gloria, Castaño Rodrigo, García Francisco, Buitrago Diego Andrés
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Stomach cancer
Gastric cancer
Familial aggregation
Genetic predisposition
Homologous recombination
Germline variants
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002038
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