Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1

Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1

Ectopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance. Here, we show that impaired MPST-derived hydrogen sulfide (H2S) signaling contributes to obesity-related SKM dysfunction. Muscle tissues fro...

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Main Authors: M. Smimmo, V. Casale, D. D'Andrea, I. Bello, N. Iaccarino, F. Romano, V. Brancaleone, E. Panza, R. d’Emmanuele di Villa Bianca, A. Katsouda, E. Mitidieri, I. Antoniadou, A. Papapetropoulos, F. Maione, S. Castaldo, M. Friuli, A. Romano, S. Gaetani, R. Sorrentino, A. Randazzo, G. Cirino, M. Bucci, M. Filipovic, V. Vellecco
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Redox Biology
Subjects:
H2S donors
Skeletal muscle
Persulfidation
Sodium palmitate
Db/db mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001582
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