Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response
This study aimed to investigate the effect of enamel caries lesion baseline severity on fluoride dose-response under pH cycling conditions. Early caries lesions were created in human enamel specimens at four different severities (8, 16, 24, and 36 h). Lesions were allocated to treatment groups (0, 8...
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| Format: | Article |
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Wiley
2017-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2017/4321925 |
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| author | Frank Lippert |
| author_facet | Frank Lippert |
| author_sort | Frank Lippert |
| collection | DOAJ |
| description | This study aimed to investigate the effect of enamel caries lesion baseline severity on fluoride dose-response under pH cycling conditions. Early caries lesions were created in human enamel specimens at four different severities (8, 16, 24, and 36 h). Lesions were allocated to treatment groups (0, 83, and 367 ppm fluoride as sodium fluoride) based on Vickers surface microhardness (VHN) and pH cycled for 5 d. The cycling model comprised 3 × 1 min fluoride treatments sandwiched between 2 × 60 min demineralization challenges with specimens stored in artificial saliva in between. VHN was measured again and changes versus lesion baseline were calculated (ΔVHN). Data were analyzed using two-way ANOVA (p<0.05). Increased demineralization times led to increased surface softening. The lesion severity×fluoride concentration interaction was significant (p<0.001). Fluoride dose-response was observed in all groups. Lesions initially demineralized for 16 and 8 h showed similar overall rehardening (ΔVHN) and more than 24 and 36 h lesions, which were similar. The 8 h lesions showed the greatest fluoride response differential (367 versus 0 ppm F) which diminished with increasing lesion baseline severity. The extent of rehardening as a result of the 0 ppm F treatment increased with increasing lesion baseline severity, whereas it decreased for the fluoride treatments. In conclusion, lesion baseline severity impacts the extent of the fluoride dose-response. |
| format | Article |
| id | doaj-art-8b66f407267f40fc92f8a63b467523a5 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-8b66f407267f40fc92f8a63b467523a52025-02-03T01:12:36ZengWileyInternational Journal of Dentistry1687-87281687-87362017-01-01201710.1155/2017/43219254321925Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-ResponseFrank Lippert0Indiana University School of Dentistry, Department of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indianapolis, IN, USAThis study aimed to investigate the effect of enamel caries lesion baseline severity on fluoride dose-response under pH cycling conditions. Early caries lesions were created in human enamel specimens at four different severities (8, 16, 24, and 36 h). Lesions were allocated to treatment groups (0, 83, and 367 ppm fluoride as sodium fluoride) based on Vickers surface microhardness (VHN) and pH cycled for 5 d. The cycling model comprised 3 × 1 min fluoride treatments sandwiched between 2 × 60 min demineralization challenges with specimens stored in artificial saliva in between. VHN was measured again and changes versus lesion baseline were calculated (ΔVHN). Data were analyzed using two-way ANOVA (p<0.05). Increased demineralization times led to increased surface softening. The lesion severity×fluoride concentration interaction was significant (p<0.001). Fluoride dose-response was observed in all groups. Lesions initially demineralized for 16 and 8 h showed similar overall rehardening (ΔVHN) and more than 24 and 36 h lesions, which were similar. The 8 h lesions showed the greatest fluoride response differential (367 versus 0 ppm F) which diminished with increasing lesion baseline severity. The extent of rehardening as a result of the 0 ppm F treatment increased with increasing lesion baseline severity, whereas it decreased for the fluoride treatments. In conclusion, lesion baseline severity impacts the extent of the fluoride dose-response.http://dx.doi.org/10.1155/2017/4321925 |
| spellingShingle | Frank Lippert Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response International Journal of Dentistry |
| title | Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response |
| title_full | Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response |
| title_fullStr | Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response |
| title_full_unstemmed | Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response |
| title_short | Effect of Enamel Caries Lesion Baseline Severity on Fluoride Dose-Response |
| title_sort | effect of enamel caries lesion baseline severity on fluoride dose response |
| url | http://dx.doi.org/10.1155/2017/4321925 |
| work_keys_str_mv | AT franklippert effectofenamelcarieslesionbaselineseverityonfluoridedoseresponse |