The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe
Background. The main objective was to determine the impact of herbal drug use on adverse drug reactions in patients on antiretroviral therapy (ART). Methodology. Patients receiving first-line ART from the national roll-out program participated in this cross-sectional study. Participants were intervi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2012/434171 |
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| author | Tinashe Mudzviti Charles C. Maponga Star Khoza Qing Ma Gene D. Morse |
| author_facet | Tinashe Mudzviti Charles C. Maponga Star Khoza Qing Ma Gene D. Morse |
| author_sort | Tinashe Mudzviti |
| collection | DOAJ |
| description | Background. The main objective was to determine the impact of herbal drug use on adverse drug reactions in patients on antiretroviral therapy (ART). Methodology. Patients receiving first-line ART from the national roll-out program participated in this cross-sectional study. Participants were interviewed and a data collection sheet was used to collect information from the corresponding medical record. Results. The majority (98.2%) of participants were using at least one herbal drug together with ART. The most common herbal remedies used were Allium Sativum (72.7%), Bidens pilosa (66.0%), Eucalyptus globulus (52.3%), Moringa oleifera (44.1%), Lippia javanica (36.3%), and Peltoforum africanum (34.3%). Two indigenous herbs, Musakavakadzi (OR=0.25; 95% CI 0.076–0.828) and Peltoforum africanum (OR=0.495; 95% CI 0.292–0.839) reduced the occurrence of adverse drug events. Conclusions. The use of herbal drugs is high in the HIV-infected population and there is need for pharmacovigilance programs to recognize the role they play in altering ADR profiles. |
| format | Article |
| id | doaj-art-8b546022f41b4a7a8d1f04e6ef273075 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-8b546022f41b4a7a8d1f04e6ef2730752025-02-03T01:32:01ZengWileyAIDS Research and Treatment2090-12402090-12592012-01-01201210.1155/2012/434171434171The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in ZimbabweTinashe Mudzviti0Charles C. Maponga1Star Khoza2Qing Ma3Gene D. Morse4School of Pharmacy, University of Zimbabwe, P.O. Box MP167, Mount Pleasant, Harare, ZimbabweSchool of Pharmacy, University of Zimbabwe, P.O. Box MP167, Mount Pleasant, Harare, ZimbabweDepartment of Clinical Pharmacology, University of Zimbabwe, College of Health Sciences, P.O. Box A178, Avondale, Harare, ZimbabweSchool of Pharmacy and Pharmaceutical Sciences and the Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, SUNY, 701 Ellicott Street, Buffalo, NY 14203, USASchool of Pharmacy and Pharmaceutical Sciences and the Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, SUNY, 701 Ellicott Street, Buffalo, NY 14203, USABackground. The main objective was to determine the impact of herbal drug use on adverse drug reactions in patients on antiretroviral therapy (ART). Methodology. Patients receiving first-line ART from the national roll-out program participated in this cross-sectional study. Participants were interviewed and a data collection sheet was used to collect information from the corresponding medical record. Results. The majority (98.2%) of participants were using at least one herbal drug together with ART. The most common herbal remedies used were Allium Sativum (72.7%), Bidens pilosa (66.0%), Eucalyptus globulus (52.3%), Moringa oleifera (44.1%), Lippia javanica (36.3%), and Peltoforum africanum (34.3%). Two indigenous herbs, Musakavakadzi (OR=0.25; 95% CI 0.076–0.828) and Peltoforum africanum (OR=0.495; 95% CI 0.292–0.839) reduced the occurrence of adverse drug events. Conclusions. The use of herbal drugs is high in the HIV-infected population and there is need for pharmacovigilance programs to recognize the role they play in altering ADR profiles.http://dx.doi.org/10.1155/2012/434171 |
| spellingShingle | Tinashe Mudzviti Charles C. Maponga Star Khoza Qing Ma Gene D. Morse The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe AIDS Research and Treatment |
| title | The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe |
| title_full | The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe |
| title_fullStr | The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe |
| title_full_unstemmed | The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe |
| title_short | The Impact of Herbal Drug Use on Adverse Drug Reaction Profiles of Patients on Antiretroviral Therapy in Zimbabwe |
| title_sort | impact of herbal drug use on adverse drug reaction profiles of patients on antiretroviral therapy in zimbabwe |
| url | http://dx.doi.org/10.1155/2012/434171 |
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