7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.141 |
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| author | Auri R. Duval Pedro H. Carvalho Maieli C. Soares Daniela P. Gouvêa Geonir M. Siqueira Rafael G. Lund Wilson Cunico |
| author_facet | Auri R. Duval Pedro H. Carvalho Maieli C. Soares Daniela P. Gouvêa Geonir M. Siqueira Rafael G. Lund Wilson Cunico |
| author_sort | Auri R. Duval |
| collection | DOAJ |
| description | Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents. |
| format | Article |
| id | doaj-art-8afd6c2cb12a445b99ee5b089b2ebd1c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8afd6c2cb12a445b99ee5b089b2ebd1c2025-02-03T06:14:12ZengWileyThe Scientific World Journal1537-744X2011-01-01111489149510.1100/tsw.2011.1417-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal ActivityAuri R. Duval0Pedro H. Carvalho1Maieli C. Soares2Daniela P. Gouvêa3Geonir M. Siqueira4Rafael G. Lund5Wilson Cunico6NuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, BrazilLaboratório de Microbiologia Oral, Faculdade de Odontologia, Universidade Federal de Pelotas, Pelotas, RS, BrazilNuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, BrazilNuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, BrazilNuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, BrazilLaboratório de Microbiologia Oral, Faculdade de Odontologia, Universidade Federal de Pelotas, Pelotas, RS, BrazilNuQuiA—Núcleo de Química Aplicada, Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas, Campus Universitário, Pelotas, RS, BrazilFifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.http://dx.doi.org/10.1100/tsw.2011.141 |
| spellingShingle | Auri R. Duval Pedro H. Carvalho Maieli C. Soares Daniela P. Gouvêa Geonir M. Siqueira Rafael G. Lund Wilson Cunico 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity The Scientific World Journal |
| title | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
| title_full | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
| title_fullStr | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
| title_full_unstemmed | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
| title_short | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
| title_sort | 7 chloroquinolin 4 yl arylhydrazone derivatives synthesis and antifungal activity |
| url | http://dx.doi.org/10.1100/tsw.2011.141 |
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