TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression

TGF‐β regulates the release of breast cancer cell‐derived extracellular vesicles and the sorting of their protein cargo by downregulating RAB27B expression

Abstract Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. The cytokine transforming growth factor‐β (TGF‐β) facilitates cancer progression via EVs secreted by cancer cells, which act on recipient cells in the tumour microenvironment....

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Bibliographic Details
Main Authors: Chao Li, Agustin Enciso‐Martinez, Roman I. Koning, Mona Shahsavari, Peter ten Dijke
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of Extracellular Vesicles
Subjects:
CD8+ T cells
extracellular vesicles
multivesicular bodies
RAB27B
release
TGF‐β
Online Access:https://doi.org/10.1002/jev2.70026
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https://doi.org/10.1002/jev2.70026

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