The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells

The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells

Bone is a dynamic tissue that is constantly remodeled throughout adult life. Recently, it has been shown that bone turnover decreases shortly after food consumption. This process has been linked to the fermentation of non-digestible food ingredients such as inulin by gut microbes, which results in t...

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Main Authors: Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Endocrinology
Subjects:
G protein-coupled receptors
Gpr41/43
short-chain fatty acids (SCFAs)
acetate
osteoblasts
bone formation
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1392418/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1392418/full

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