An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody

An Effective Prophylactic and Therapeutic Protection Against Botulinum Type A Intoxication in Mice and Rabbits Using a Humanized Monoclonal Antibody

Botulinum neurotoxins (BoNTs) are the most potent toxins on Earth and are classified as Category A biological agents. BoNTs lead to paralysis in humans and cause botulism. Antibody therapeutics can effectively treat toxin-mediated infectious diseases. In this study, we generated a pharmaceutical hum...

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Bibliographic Details
Main Authors: Chi Ho Yu, Young-Jo Song, Dong Hyun Song, Hae Eun Joe, Chang-Hwan Kim, Hyungseok Yun, Na Young Kim, Euni Sim, Seong Tae Jeong, Gyeung Haeng Hur
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Toxins
Subjects:
botulinum neurotoxin
monoclonal antibody
mouse
rabbit
Online Access:https://www.mdpi.com/2072-6651/17/3/138
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