A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission

A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission

Abstract Background Mixed infection with multiple strains of the same pathogen in a single host can present clinical and analytical challenges. Whole genome sequence (WGS) data can identify signals of multiple strains in samples, though the precision of previous methods can be improved. Here, we pre...

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Bibliographic Details
Main Authors: Benjamin Sobkowiak, Patrick Cudahy, Melanie H. Chitwood, Taane G. Clark, Caroline Colijn, Louis Grandjean, Katharine S. Walter, Valeriu Crudu, Ted Cohen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Genome Medicine
Subjects:
Mycobacterium tuberculosis
Mixed infection
Genomic epidemiology
Tuberculosis
Whole genome sequencing
Bioinformatics
Online Access:https://doi.org/10.1186/s13073-025-01430-y
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