Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer
Aim. Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and 2 colorectal cancer is uncertain. In the present study, the incidence of EMVI and the hazard ratio for recurrence in patients with stage 1 a...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/1598670 |
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| author | E. E. van Eeghen M. J. Flens M. M. R. Mulder R. J. L. F. Loffeld |
| author_facet | E. E. van Eeghen M. J. Flens M. M. R. Mulder R. J. L. F. Loffeld |
| author_sort | E. E. van Eeghen |
| collection | DOAJ |
| description | Aim. Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and 2 colorectal cancer is uncertain. In the present study, the incidence of EMVI and the hazard ratio for recurrence in patients with stage 1 and 2 colon cancer were studied. Methods. 184 patients treated for stage 1 and 2 colon cancer were included with a follow-up of at least 5 years. Chart review was performed and EMVI was assessed by two separate pathologists. EMVI was scored with additional caldesmon staining on the resection specimen. Primary outcomes were recurrence-free survival (RFS) measured through the Cox regression analysis and prevalence of EMVI. Results. There were 10 cases of EMVI and 3 cases of intramural venous invasion (IMVI) all occurring in patients with stage 2 disease corresponding to a prevalence of 9%. Thirty-one percent of the patients with venous invasion experienced recurrence versus 14% in patients without, corresponding with a hazard ratio of 2.39 (p=0.11). Conclusion. The present study demonstrates a trend towards an increased risk of recurrence in patients with stage 2 colon cancer with venous invasion. This warrants consideration of adjuvant chemotherapy despite the lack of lymph node metastases. |
| format | Article |
| id | doaj-art-8ab79c5b62794bebab6e63f930ab12a3 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8ab79c5b62794bebab6e63f930ab12a32025-02-03T01:02:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/15986701598670Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon CancerE. E. van Eeghen0M. J. Flens1M. M. R. Mulder2R. J. L. F. Loffeld3Department of Internal Medicine, Zaans Medisch Centrum, Zaandam, NetherlandsDepartment of Pathology, Zaans Medisch Centrum, Zaandam, NetherlandsDepartment of Pathology, Zaans Medisch Centrum, Zaandam, NetherlandsDepartment of Internal Medicine, Zaans Medisch Centrum, Zaandam, NetherlandsAim. Extramural venous invasion (EMVI) is a prognostic indicator in patients with colorectal cancer. However, its additional value in patients with stage 1 and 2 colorectal cancer is uncertain. In the present study, the incidence of EMVI and the hazard ratio for recurrence in patients with stage 1 and 2 colon cancer were studied. Methods. 184 patients treated for stage 1 and 2 colon cancer were included with a follow-up of at least 5 years. Chart review was performed and EMVI was assessed by two separate pathologists. EMVI was scored with additional caldesmon staining on the resection specimen. Primary outcomes were recurrence-free survival (RFS) measured through the Cox regression analysis and prevalence of EMVI. Results. There were 10 cases of EMVI and 3 cases of intramural venous invasion (IMVI) all occurring in patients with stage 2 disease corresponding to a prevalence of 9%. Thirty-one percent of the patients with venous invasion experienced recurrence versus 14% in patients without, corresponding with a hazard ratio of 2.39 (p=0.11). Conclusion. The present study demonstrates a trend towards an increased risk of recurrence in patients with stage 2 colon cancer with venous invasion. This warrants consideration of adjuvant chemotherapy despite the lack of lymph node metastases.http://dx.doi.org/10.1155/2017/1598670 |
| spellingShingle | E. E. van Eeghen M. J. Flens M. M. R. Mulder R. J. L. F. Loffeld Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer Gastroenterology Research and Practice |
| title | Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer |
| title_full | Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer |
| title_fullStr | Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer |
| title_full_unstemmed | Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer |
| title_short | Extramural Venous Invasion as Prognostic Factor of Recurrence in Stage 1 and 2 Colon Cancer |
| title_sort | extramural venous invasion as prognostic factor of recurrence in stage 1 and 2 colon cancer |
| url | http://dx.doi.org/10.1155/2017/1598670 |
| work_keys_str_mv | AT eevaneeghen extramuralvenousinvasionasprognosticfactorofrecurrenceinstage1and2coloncancer AT mjflens extramuralvenousinvasionasprognosticfactorofrecurrenceinstage1and2coloncancer AT mmrmulder extramuralvenousinvasionasprognosticfactorofrecurrenceinstage1and2coloncancer AT rjlfloffeld extramuralvenousinvasionasprognosticfactorofrecurrenceinstage1and2coloncancer |