In vivo base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease

In vivo base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease

Cardiovascular disease (CVD) is the leading cause of death globally and is exacerbated by elevated blood levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs). Existing approaches for decreasing blood lipid levels rely on daily medications, leading to poor patient adherence....

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Bibliographic Details
Main Authors: Jennifer Khirallah, Hanan Bloomer, Douglas Wich, Changfeng Huang, J. Noah Workman, Yamin Li, Gregory A. Newby, David R. Liu, Qiaobing Xu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
CRISPR-Cas9
base editing
gene editing
angiopoietin-like protein-3
cardiovascular disease
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312500040X
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