Mapping subcellular RNA localization with proximity labeling
The subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate. However, it remains chal...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Science Publishing & Media Ltd.
2024-08-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024147 |
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| _version_ | 1832590341824315392 |
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| author | Liu Jiapeng Zhong Binglin Li Shuojun Han Shuo |
| author_facet | Liu Jiapeng Zhong Binglin Li Shuojun Han Shuo |
| author_sort | Liu Jiapeng |
| collection | DOAJ |
| description | The subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate. However, it remains challenging to effectively enrich and catalogue RNAs from various subcellular structures using traditional approaches. In recent years, proximity labeling has emerged as an alternative strategy for efficient isolation and purification of RNA from these intricate subcellular compartments. This review focuses on examining RNA-related proximity labeling tools and exploring their application in elucidating the spatiotemporal regulation of RNA at the subcellular level. |
| format | Article |
| id | doaj-art-8ab43acacadc4247ba0303b23f0f3917 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-8ab43acacadc4247ba0303b23f0f39172025-01-24T00:56:44ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-08-015710110710.3724/abbs.202414720d259ccMapping subcellular RNA localization with proximity labelingLiu Jiapeng0Zhong Binglin1Li Shuojun2Han Shuo3[][][][]The subcellular localization of RNA is critical to a variety of physiological and pathological processes. Dissecting the spatiotemporal regulation of the transcriptome is key to understanding cell function and fate. However, it remains challenging to effectively enrich and catalogue RNAs from various subcellular structures using traditional approaches. In recent years, proximity labeling has emerged as an alternative strategy for efficient isolation and purification of RNA from these intricate subcellular compartments. This review focuses on examining RNA-related proximity labeling tools and exploring their application in elucidating the spatiotemporal regulation of RNA at the subcellular level.https://www.sciengine.com/doi/10.3724/abbs.2024147RNA localizationproximity labelingspatiotemporal regulationsubcellular compartments |
| spellingShingle | Liu Jiapeng Zhong Binglin Li Shuojun Han Shuo Mapping subcellular RNA localization with proximity labeling Acta Biochimica et Biophysica Sinica RNA localization proximity labeling spatiotemporal regulation subcellular compartments |
| title | Mapping subcellular RNA localization with proximity labeling |
| title_full | Mapping subcellular RNA localization with proximity labeling |
| title_fullStr | Mapping subcellular RNA localization with proximity labeling |
| title_full_unstemmed | Mapping subcellular RNA localization with proximity labeling |
| title_short | Mapping subcellular RNA localization with proximity labeling |
| title_sort | mapping subcellular rna localization with proximity labeling |
| topic | RNA localization proximity labeling spatiotemporal regulation subcellular compartments |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024147 |
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