Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

Cardiac bridging integrator 1 gene therapy rescues chronic non-ischemic heart failure in minipigs

Abstract Heart failure (HF) is a major cause of mortality and morbidity worldwide, yet with limited therapeutic options. Cardiac bridging integrator 1 (cBIN1), a cardiomyocyte transverse-tubule (t-tubule) scaffolding protein which organizes the calcium handling machinery, is transcriptionally reduce...

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Main Authors: Jing Li, Pia Balmaceda, Thuy Ha, Joseph R. Visker, Nicole Maalouf, Eugene Kwan, Guillaume L. Hoareau, Michel Accad, Ravi Ranjan, Craig H. Selzman, Stavros G. Drakos, Robin M. Shaw, TingTing Hong
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-024-00380-0
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https://doi.org/10.1038/s41536-024-00380-0

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