Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects
Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Bet...
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2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/328697 |
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| author | Yuksel Kaya Ramazan Akdemir Huseyin Gunduz Sani Murat Orhan Bulut İbrahim Kocayigit M. Bulent Vatan M. Akif Cakar Ekrem Yeter Harun Kilic Mustafa Tarik Agac Zeydin Acar |
| author_facet | Yuksel Kaya Ramazan Akdemir Huseyin Gunduz Sani Murat Orhan Bulut İbrahim Kocayigit M. Bulent Vatan M. Akif Cakar Ekrem Yeter Harun Kilic Mustafa Tarik Agac Zeydin Acar |
| author_sort | Yuksel Kaya |
| collection | DOAJ |
| description | Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were 25.3±14.3) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure. Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant (97.3±78.6 versus 26.8±15.6, 𝑃=0.013). Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels. |
| format | Article |
| id | doaj-art-8a5ce2682f314978855f308d0f45d705 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-8a5ce2682f314978855f308d0f45d7052025-02-03T05:43:57ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/328697328697Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal DefectsYuksel Kaya0Ramazan Akdemir1Huseyin Gunduz2Sani Murat3Orhan Bulut4İbrahim Kocayigit5M. Bulent Vatan6M. Akif Cakar7Ekrem Yeter8Harun Kilic9Mustafa Tarik Agac10Zeydin Acar11Department of Cardiology, Van Yüksek Ihtisas Hospital, 65200 Van, TurkeyDepartment of Cardiology, Faculty of Medicine, Sakarya University, Esentepe, 54054 Sakarya, TurkeyDepartment of Cardiology, Faculty of Medicine, Sakarya University, Esentepe, 54054 Sakarya, TurkeyDepartment of Cardiology, Research and Education Hospital, Dıskapi/Etlik Ihtisas, 06110 Ankara, TurkeyDepartment of Cardiology, Van Yüksek Ihtisas Hospital, 65200 Van, TurkeyDepartment of Cardiology, Faculty of Medicine, Sakarya University, Esentepe, 54054 Sakarya, TurkeyDepartment of Cardiology, Faculty of Medicine, Sakarya University, Esentepe, 54054 Sakarya, TurkeyDepartment of Cardiology, Faculty of Medicine, Sakarya University, Esentepe, 54054 Sakarya, TurkeyDepartment of Cardiology, Research and Education Hospital, Dıskapi/Etlik Ihtisas, 06110 Ankara, TurkeyDepartment of Cardiology, Research and Education Hospital, Dıskapi/Etlik Ihtisas, 06110 Ankara, TurkeyDepartment of Cardiology, Ahi Evren Heart and Vascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Cardiology, Ahi Evren Heart and Vascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyBackground. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were 25.3±14.3) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure. Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant (97.3±78.6 versus 26.8±15.6, 𝑃=0.013). Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels.http://dx.doi.org/10.1100/2012/328697 |
| spellingShingle | Yuksel Kaya Ramazan Akdemir Huseyin Gunduz Sani Murat Orhan Bulut İbrahim Kocayigit M. Bulent Vatan M. Akif Cakar Ekrem Yeter Harun Kilic Mustafa Tarik Agac Zeydin Acar Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects The Scientific World Journal |
| title | Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects |
| title_full | Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects |
| title_fullStr | Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects |
| title_full_unstemmed | Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects |
| title_short | Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects |
| title_sort | changes in serum natriuretic peptide levels after percutaneous closure of small to moderate ventricular septal defects |
| url | http://dx.doi.org/10.1100/2012/328697 |
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