Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies
A critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we investigate the microwave dielectric properties...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2012/649612 |
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| _version_ | 1832552026396950528 |
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| author | Paul M. Meaney Tian Zhou Douglas Goodwin Amir Golnabi Elia A. Attardo Keith D. Paulsen |
| author_facet | Paul M. Meaney Tian Zhou Douglas Goodwin Amir Golnabi Elia A. Attardo Keith D. Paulsen |
| author_sort | Paul M. Meaney |
| collection | DOAJ |
| description | A critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we investigate the microwave dielectric properties of ex vivo trabecular bone with respect to bulk density measures. We exploit a variation in our tomographic imaging system in conjunction with a new soft prior regularization scheme that allows us to accurately recover the dielectric properties of small, regularly shaped and previously spatially defined volumes. We studied six excised porcine bone samples from which we extracted cylindrically shaped trabecular specimens from the femoral heads and carefully demarrowed each preparation. The samples were subsequently treated in an acid bath to incrementally remove volumes of hydroxyapatite, and we tested them with both the microwave measurement system and a micro-CT scanner. The measurements were performed at five density levels for each sample. The results show a strong correlation between both the permittivity and conductivity and bone volume fraction and suggest that microwave imaging may be a good candidate for evaluating overall bone health. |
| format | Article |
| id | doaj-art-8a4ab75077e0474abf8643980bd8d7a3 |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-8a4ab75077e0474abf8643980bd8d7a32025-02-03T05:59:47ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/649612649612Bone Dielectric Property Variation as a Function of Mineralization at Microwave FrequenciesPaul M. Meaney0Tian Zhou1Douglas Goodwin2Amir Golnabi3Elia A. Attardo4Keith D. Paulsen5Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAKuang-Chi Institute of Advanced Technology, Shenzhen, Guangdong 518000, ChinaDartmouth-Hitchcock Medical Center, Lebanon NH, 03756, USAThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAThayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAA critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we investigate the microwave dielectric properties of ex vivo trabecular bone with respect to bulk density measures. We exploit a variation in our tomographic imaging system in conjunction with a new soft prior regularization scheme that allows us to accurately recover the dielectric properties of small, regularly shaped and previously spatially defined volumes. We studied six excised porcine bone samples from which we extracted cylindrically shaped trabecular specimens from the femoral heads and carefully demarrowed each preparation. The samples were subsequently treated in an acid bath to incrementally remove volumes of hydroxyapatite, and we tested them with both the microwave measurement system and a micro-CT scanner. The measurements were performed at five density levels for each sample. The results show a strong correlation between both the permittivity and conductivity and bone volume fraction and suggest that microwave imaging may be a good candidate for evaluating overall bone health.http://dx.doi.org/10.1155/2012/649612 |
| spellingShingle | Paul M. Meaney Tian Zhou Douglas Goodwin Amir Golnabi Elia A. Attardo Keith D. Paulsen Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies International Journal of Biomedical Imaging |
| title | Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies |
| title_full | Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies |
| title_fullStr | Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies |
| title_full_unstemmed | Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies |
| title_short | Bone Dielectric Property Variation as a Function of Mineralization at Microwave Frequencies |
| title_sort | bone dielectric property variation as a function of mineralization at microwave frequencies |
| url | http://dx.doi.org/10.1155/2012/649612 |
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