The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study
Introduction Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendeli...
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Termedia Publishing House
2024-05-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-causal-association-of-cheese-intake-with-type-2-diabetes-mellitus-results-from,188068,0,2.html |
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| author | Tao Zhong Yu-qing Huang Guiming Wang |
| author_facet | Tao Zhong Yu-qing Huang Guiming Wang |
| author_sort | Tao Zhong |
| collection | DOAJ |
| description | Introduction
Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendelian randomization (MR) study.
Material and methods
Summary cheese intake statistics were obtained from UK Biobank and publicly available genome-wide association studies (GWAS) for type 2 diabetes from IEU OpenGWAS, FinnGen Biobank, EBI GWAS, and Biobank Japan. The primary method was pooled meta-analysis with the inverse variance weighting method. The sensitivity analyses included MR-Egger regression, weighted median, weighted mode, and leave-one-out. MR estimations of causation were reported as odds ratios (OR) with 95% confidence intervals (CI).
Results
In the pooled meta-analysis of the fixed and random effect model, the combined ORs for type 2 diabetes were 0.58 (95% CI: 0.50–0.68, p 0.05) but heterogeneity (all p < 0.05).
Conclusions
We found that moderate consumption of beneficial cheese may reduce the risk of type 2 diabetes. These findings suggested that increasing cheese intake appropriate for humans may help prevent and control type 2 diabetes. |
| format | Article |
| id | doaj-art-8a3e867fec864d848eca8a798ecbdd1e |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-8a3e867fec864d848eca8a798ecbdd1e2025-01-27T10:45:12ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-05-012061930194210.5114/aoms/188068188068The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization studyTao Zhong0Yu-qing Huang1Guiming Wang2Department of Cardiology, The First Hospital of Nanchang，Nanchang, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, ChinaDepartment of Cardiology, The First Hospital of Nanchang，Nanchang, ChinaIntroduction Worldwide, type 2 diabetes is a major health concern with numerous risk factors. In observational studies, cheese consumption has been linked to type 2 diabetes, but it is still unclear whether this relationship is causal. To evaluate this relationship, we performed a two-sample Mendelian randomization (MR) study. Material and methods Summary cheese intake statistics were obtained from UK Biobank and publicly available genome-wide association studies (GWAS) for type 2 diabetes from IEU OpenGWAS, FinnGen Biobank, EBI GWAS, and Biobank Japan. The primary method was pooled meta-analysis with the inverse variance weighting method. The sensitivity analyses included MR-Egger regression, weighted median, weighted mode, and leave-one-out. MR estimations of causation were reported as odds ratios (OR) with 95% confidence intervals (CI). Results In the pooled meta-analysis of the fixed and random effect model, the combined ORs for type 2 diabetes were 0.58 (95% CI: 0.50–0.68, p 0.05) but heterogeneity (all p < 0.05). Conclusions We found that moderate consumption of beneficial cheese may reduce the risk of type 2 diabetes. These findings suggested that increasing cheese intake appropriate for humans may help prevent and control type 2 diabetes.https://www.archivesofmedicalscience.com/The-causal-association-of-cheese-intake-with-type-2-diabetes-mellitus-results-from,188068,0,2.htmlcheese intaketype 2 diabetesdiabetesmendelian randomizationcausal association |
| spellingShingle | Tao Zhong Yu-qing Huang Guiming Wang The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study Archives of Medical Science cheese intake type 2 diabetes diabetes mendelian randomization causal association |
| title | The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study |
| title_full | The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study |
| title_fullStr | The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study |
| title_full_unstemmed | The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study |
| title_short | The causal association of cheese intake with type 2 diabetes mellitus: results from a two-sample Mendelian randomization study |
| title_sort | causal association of cheese intake with type 2 diabetes mellitus results from a two sample mendelian randomization study |
| topic | cheese intake type 2 diabetes diabetes mendelian randomization causal association |
| url | https://www.archivesofmedicalscience.com/The-causal-association-of-cheese-intake-with-type-2-diabetes-mellitus-results-from,188068,0,2.html |
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