Reveal the potent antidepressant effects of Zhi-Zi-Hou-Pu Decoction based on integrated network pharmacology and DDI analysis by deep learning

Reveal the potent antidepressant effects of Zhi-Zi-Hou-Pu Decoction based on integrated network pharmacology and DDI analysis by deep learning

Background and objective: The multi-targets and multi-components of Traditional Chinese medicine (TCM) coincide with the complex pathogenesis of depression. Zhi-Zi-Hou-Pu Decoction (ZZHPD) has been approved in clinical medication with good antidepression effects for centuries, while the mechanisms u...

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Bibliographic Details
Main Authors: Zhiwen Zhang, Xiaojing Li, Zihui Huang, Zhenxing Pan, Lingjie Li, Yang Wang, Siwei Wu, Yan Xing, Guanlin Xiao, Yan He, Dake Cai, Xujie Liu
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
ZZHPD
Depression
Deep learning
Network pharmacology
Drug-drug interactions
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024147573
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