Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point
Myofascial trigger point (MTrP), an iconic characteristic of myofascial pain syndrome (MPS), can induce cerebral cortex changes including altered cortical excitability and connectivity. The corresponding characteristically reactive cortex is still ambiguous. Seventeen participants with latent MTrPs...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/4416672 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552993408417792 |
|---|---|
| author | Xinglou Li Meiling Luo Yan Gong Ning Xu Congcong Huo Hui Xie Shouwei Yue Zengyong Li Yonghui Wang |
| author_facet | Xinglou Li Meiling Luo Yan Gong Ning Xu Congcong Huo Hui Xie Shouwei Yue Zengyong Li Yonghui Wang |
| author_sort | Xinglou Li |
| collection | DOAJ |
| description | Myofascial trigger point (MTrP), an iconic characteristic of myofascial pain syndrome (MPS), can induce cerebral cortex changes including altered cortical excitability and connectivity. The corresponding characteristically reactive cortex is still ambiguous. Seventeen participants with latent MTrPs underwent functional near-infrared spectroscopy (fNIRS) to collect cerebral oxygenation hemoglobin (Δ[oxy-Hb]) signals. The Δ[oxy-Hb] signals of the left/right prefrontal cortex (L/R PFC), left/right motor cortex (L/R MC), and left/right occipital lobe (L/R OL) of the subjects were measured using functional near-infrared spectroscopy (fNIRS) in the resting state, nonmyofascial trigger point (NMTrP), state and MTrP state. The data investigated the latent MTrP-induced changes in brain activity and effective connectivity (EC) within the nonsensory cortex. The parameter wavelet amplitude (WA) was used to describe cortical activation, EC to show brain network connectivity, and main coupling direction (mCD) to exhibit the dominant connectivity direction in different frequency bands. An increasing trend of WA and a decreasing trend of EC values were observed in the PFC. The interregional mCD was primarily shifted from a unidirectional to bidirectional connection, especially from PFC to MC or OL, when responding to manual stimulation during the MTrP state compared with resting state and NMTrP state in the intervals III, IV, and V. This study demonstrates that the nonsensory cortex PFC, MC, and OL can participate in the cortical reactions induced by stimulation of a latent MTrP. Additionally, the PFC shows nonnegligible higher activation and weakened regulation than other brain regions. Thus, the PFC may be responsible for the central cortical regulation of a latent MTrP. This trial is registered with ChiCTR2100048433. |
| format | Article |
| id | doaj-art-8a271f10171b4d4c9e12b8a29e03027d |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8a271f10171b4d4c9e12b8a29e03027d2025-02-03T05:57:23ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/4416672Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger PointXinglou Li0Meiling Luo1Yan Gong2Ning Xu3Congcong Huo4Hui Xie5Shouwei Yue6Zengyong Li7Yonghui Wang8Rehabilitation CenterRehabilitation CenterDepartment of Physical Medicine and RehabilitationSchool of Rehabilitation Medicine of Shandong University of Traditional Chinese MedicineKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationRehabilitation CenterBeijing Key Laboratory of Rehabilitation Technical Aids for Old–Age DisabilityRehabilitation CenterMyofascial trigger point (MTrP), an iconic characteristic of myofascial pain syndrome (MPS), can induce cerebral cortex changes including altered cortical excitability and connectivity. The corresponding characteristically reactive cortex is still ambiguous. Seventeen participants with latent MTrPs underwent functional near-infrared spectroscopy (fNIRS) to collect cerebral oxygenation hemoglobin (Δ[oxy-Hb]) signals. The Δ[oxy-Hb] signals of the left/right prefrontal cortex (L/R PFC), left/right motor cortex (L/R MC), and left/right occipital lobe (L/R OL) of the subjects were measured using functional near-infrared spectroscopy (fNIRS) in the resting state, nonmyofascial trigger point (NMTrP), state and MTrP state. The data investigated the latent MTrP-induced changes in brain activity and effective connectivity (EC) within the nonsensory cortex. The parameter wavelet amplitude (WA) was used to describe cortical activation, EC to show brain network connectivity, and main coupling direction (mCD) to exhibit the dominant connectivity direction in different frequency bands. An increasing trend of WA and a decreasing trend of EC values were observed in the PFC. The interregional mCD was primarily shifted from a unidirectional to bidirectional connection, especially from PFC to MC or OL, when responding to manual stimulation during the MTrP state compared with resting state and NMTrP state in the intervals III, IV, and V. This study demonstrates that the nonsensory cortex PFC, MC, and OL can participate in the cortical reactions induced by stimulation of a latent MTrP. Additionally, the PFC shows nonnegligible higher activation and weakened regulation than other brain regions. Thus, the PFC may be responsible for the central cortical regulation of a latent MTrP. This trial is registered with ChiCTR2100048433.http://dx.doi.org/10.1155/2022/4416672 |
| spellingShingle | Xinglou Li Meiling Luo Yan Gong Ning Xu Congcong Huo Hui Xie Shouwei Yue Zengyong Li Yonghui Wang Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point Neural Plasticity |
| title | Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point |
| title_full | Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point |
| title_fullStr | Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point |
| title_full_unstemmed | Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point |
| title_short | Altered Brain Activity and Effective Connectivity within the Nonsensory Cortex during Stimulation of a Latent Myofascial Trigger Point |
| title_sort | altered brain activity and effective connectivity within the nonsensory cortex during stimulation of a latent myofascial trigger point |
| url | http://dx.doi.org/10.1155/2022/4416672 |
| work_keys_str_mv | AT xinglouli alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT meilingluo alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT yangong alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT ningxu alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT congconghuo alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT huixie alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT shouweiyue alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT zengyongli alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint AT yonghuiwang alteredbrainactivityandeffectiveconnectivitywithinthenonsensorycortexduringstimulationofalatentmyofascialtriggerpoint |