Germline microRNA-based signatures predict toxicity and response to anti-CTLA-4 therapy

Germline microRNA-based signatures predict toxicity and response to anti-CTLA-4 therapy

Abstract Background Germline microRNA-based variants (mirSNPs) have been shown to be predictive biomarkers of toxicity and tumor response across cancer treatments, including to anti-PD1/PDL1 immune checkpoint therapy. CTLA-4 inhibitors are another immune checkpoint inhibitor with known significant t...

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Main Authors: Joanne B. Weidhaas, Kristen M. McGreevy, Nicholas Marco, Nora Sundahl, Christopher R. Cabanski, Christine Spencer, Theresa LaVallee, Piet Ost, Donatello Telesca
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-025-06842-3
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