Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients
Background: Cardiovascular diseases (CVDs) are highly prevalent among the end-stage renal disease (ESRD) patients. Prognostic value of cardiac troponin I (cTnI) in patients with asymptomatic ESRD is less conclusive. This study was an observational study to evaluate correlation of first admitted cTnI...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jrms.jrms_658_23 |
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| author | Shahram Taheri Golbarg Ghomi Alireza Nematollahi Sayed Mohsen Hosseini |
| author_facet | Shahram Taheri Golbarg Ghomi Alireza Nematollahi Sayed Mohsen Hosseini |
| author_sort | Shahram Taheri |
| collection | DOAJ |
| description | Background:
Cardiovascular diseases (CVDs) are highly prevalent among the end-stage renal disease (ESRD) patients. Prognostic value of cardiac troponin I (cTnI) in patients with asymptomatic ESRD is less conclusive. This study was an observational study to evaluate correlation of first admitted cTnI level with early and late (during 6 months) hospitalization and mortality of ESRD patient admitted due to non-acute coronary and non-heart failure causes in ESRD patients.
Materials and Methods:
In this prospective observational study, 460 dialysis patients without overt CVD who were admitted at two university hospital were included and followed during 6 months. Patients’ demographic information and laboratory investigations including cTnI level and cause of admission were recorded. The association between cTnI level with in-hospital and late mortality was evaluated.
Results:
cTnI level was higher in female (35.9%), hemodialysis patients (28.1%), and patients with permanent catheter vascular access (29.4%). There were significant differences in level of triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol between patients with normal and abnormal cTnI levels (P < 0.05). Patients with abnormal cTnI levels had higher level of TG and LDL cholesterol and lower level of HDL cholesterol. cTnI levels were associated with higher in-hospital and 6-month follow-up mortality rate. In logistic regression analysis, only female gender (odds ratio [OR] =1.89, confidence interval [CI] =1.22–3.076) and TG (OR = 1.007, CI = 1.003–1.01) were positively and HDL cholesterol level (OR = 0.994, CI = 0.98–0.99) was negatively associated with increased cTnI level. cTnI level was associated with early (OR = 4.81, CI = 1.64–14.89) and late (OR = 4.31, CI = 1.61–10.96) mortality.
Conclusion:
Although in this study, cTnI level is not directly associated with cardiovascular disorders and admission and readmission causes, it is a strong predictor of early and late mortality. |
| format | Article |
| id | doaj-art-8a18a2ee9563498c9e37d6a722fcbd1d |
| institution | Kabale University |
| issn | 1735-1995 1735-7136 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj-art-8a18a2ee9563498c9e37d6a722fcbd1d2025-02-06T09:56:28ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362025-01-013018810.4103/jrms.jrms_658_23Association of cardiac troponin I level with in-hospital and late mortality in dialysis patientsShahram TaheriGolbarg GhomiAlireza NematollahiSayed Mohsen HosseiniBackground: Cardiovascular diseases (CVDs) are highly prevalent among the end-stage renal disease (ESRD) patients. Prognostic value of cardiac troponin I (cTnI) in patients with asymptomatic ESRD is less conclusive. This study was an observational study to evaluate correlation of first admitted cTnI level with early and late (during 6 months) hospitalization and mortality of ESRD patient admitted due to non-acute coronary and non-heart failure causes in ESRD patients. Materials and Methods: In this prospective observational study, 460 dialysis patients without overt CVD who were admitted at two university hospital were included and followed during 6 months. Patients’ demographic information and laboratory investigations including cTnI level and cause of admission were recorded. The association between cTnI level with in-hospital and late mortality was evaluated. Results: cTnI level was higher in female (35.9%), hemodialysis patients (28.1%), and patients with permanent catheter vascular access (29.4%). There were significant differences in level of triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol between patients with normal and abnormal cTnI levels (P < 0.05). Patients with abnormal cTnI levels had higher level of TG and LDL cholesterol and lower level of HDL cholesterol. cTnI levels were associated with higher in-hospital and 6-month follow-up mortality rate. In logistic regression analysis, only female gender (odds ratio [OR] =1.89, confidence interval [CI] =1.22–3.076) and TG (OR = 1.007, CI = 1.003–1.01) were positively and HDL cholesterol level (OR = 0.994, CI = 0.98–0.99) was negatively associated with increased cTnI level. cTnI level was associated with early (OR = 4.81, CI = 1.64–14.89) and late (OR = 4.31, CI = 1.61–10.96) mortality. Conclusion: Although in this study, cTnI level is not directly associated with cardiovascular disorders and admission and readmission causes, it is a strong predictor of early and late mortality.https://journals.lww.com/10.4103/jrms.jrms_658_23cardiac diseasescardiac-specific troponinsend-stage renal disease |
| spellingShingle | Shahram Taheri Golbarg Ghomi Alireza Nematollahi Sayed Mohsen Hosseini Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients Journal of Research in Medical Sciences cardiac diseases cardiac-specific troponins end-stage renal disease |
| title | Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients |
| title_full | Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients |
| title_fullStr | Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients |
| title_full_unstemmed | Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients |
| title_short | Association of cardiac troponin I level with in-hospital and late mortality in dialysis patients |
| title_sort | association of cardiac troponin i level with in hospital and late mortality in dialysis patients |
| topic | cardiac diseases cardiac-specific troponins end-stage renal disease |
| url | https://journals.lww.com/10.4103/jrms.jrms_658_23 |
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