Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells

Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells

Auditory neuropathy spectrum disorder (ANSD) is an auditory dysfunction disorder characterized by impaired speech comprehension. Its etiology is complex and can be broadly categorized into genetic and non-genetic factors. TMEM43 mutation is identified as a causative factor in ANSD. While some studie...

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Bibliographic Details
Main Authors: Xiaoming Kang, Lu Ma, Jie Wen, Wei Gong, Xianlin Liu, Yihan Hu, Zhili Feng, Qiancheng Jing, Yuexiang Cai, Sijun Li, Xinzhang Cai, Kai Yuan, Yong Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
auditory neuropathy spectrum disorder
TMEM43
glia-like support cells
gap junction
induced pluripotent stem cells
RNA-Seq
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1457874/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2024.1457874/full

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