Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer

Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancer

BackgroundColorectal cancer (CRC) is a heterogeneous illness influenced by intricate tumor-immune interactions and characterized by a dismal prognosis. Macrophage-mediated immunological signaling facilitates tumor proliferation and may associate inflammation in the tumor microenvironment (TME) of CR...

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Bibliographic Details
Main Authors: Wenyang Nie, Wangzheqi Zhang, Zhikai Xiahou, Yuxuan Meng, Yuhang Liu, Jingwen Zhang, Zhen Wang, Yong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
single-cell RNA sequencing
tumor microenvironment
immune signal transduction
cancer model
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637144/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1637144/full

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