RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.

RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.

Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca(2+)-induced Ca(2+)-release (CICR) mechanism...

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Main Authors: María Fernández-Velasco, Gema Ruiz-Hurtado, Angélica Rueda, Patricia Neco, Martha Mercado-Morales, Carmen Delgado, Carlo Napolitano, Silvia G Priori, Sylvain Richard, Ana María Gómez, Jean-Pierre Benitah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020863&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0020863&type=printable

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