Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors

Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors

IntroductionB-cell receptor (BCR) signaling has revealed itself as a critical pathway in the pathogenesis of B-cell lymphoma. Within this pathway, the inhibition of Bruton's tyrosine kinase (BTK) or Phosphoinositide 3-kinases (PI3Ks) alone presents encouraging efficacy in the treatment of certa...

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Bibliographic Details
Main Authors: Xenia Lainscsek, Weibo Kong, Barbara C. Rütgen, Julia Beck, Bertram Brenig, Ingo Nolte, Hugo Murua Escobar, Leila Taher
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Veterinary Science
Subjects:
canine lymphoma
tyrosine kinase inhibitors
phosphoinositide 3-kinase inhibitors
RNA-seq
differential expression analysis
co-expression network analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1577028/full
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https://www.frontiersin.org/articles/10.3389/fvets.2025.1577028/full

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